Clinical Trial: Dichloroacetate Kinetics, Metabolism and Toxicology

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title:

Brief Summary: Dichloroacetate (DCA) is a product of water chlorination and a metabolite of certain industrial solvents, thus making it a chemical of environmental concern. However, DCA is also used as an investigational drug for treating various diseases of adults and children, at doses far greater than those to which humans are normally exposed in the environment. Our research involves how DCA is metabolized by healthy adults and by children with a fatal genetic disease, congenital lactic acidosis (CLA) who are treated with DCA.

Detailed Summary:
Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Current Primary Outcome:

Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: National Institute of Environmental Health Sciences (NIEHS)

Dates:
Date Received: April 17, 2001
Date Started: December 1994
Date Completion: October 2002
Last Updated: September 1, 2006
Last Verified: September 2006