Clinical Trial: Persistent Platelet Reactivity in Acute Coronary Syndrome

Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Observational [Patient Registry]

Official Title: Persistent Platelet Reactivity in Acute Coronary Syndrome

Brief Summary: Study of persistent platelet reactivity during acute coronary syndrome. Patients are included at admission to the hospital. Platelet aggregation is evaluated by platelet function testing after blood sampling during hospitalization. No changes in treatment is planned.

Detailed Summary: Blood samples are performed on day 2 and 4 and collected with usual blood samples and analyzed by the laboratory. Maximal aggregation intensity and velocity are measured by light transmission aggregometry induced by arachidonic acid (AA) or adenosine diphosphate (ADP). Platelet function analyzer will be also used. No changes in treatment in response to the results is planned.
Sponsor: Hopital Lariboisière

Current Primary Outcome: maximum aggregation intensity [ Time Frame: day 2 ]

Light transmission aggregometry following exposition to arachidonic acid 0.5mg/ml during the acute phase (day2-day 5)


Original Primary Outcome: maximum agregation intensity [ Time Frame: day 2 ]

Light transimssion agregometry following exposition to arachidonic acid during the acute phase (day2-day 5)


Current Secondary Outcome:

  • Maximum aggregation intensity [ Time Frame: Day 2 ]
    Light transmission aggregometry following exposition to adenosine diphosphate during the acute phase (day2-day 5) and during the chronic phase (day 30-day 60)
  • Maximum aggregation intensity [ Time Frame: Chronic phase (day 30 to day 60) ]
    Light transmission aggregometry following exposition to arachidonic acid 0.5mg/ml during the chronic phase (day 30-day 60)


Original Secondary Outcome:

  • Maximum agregation intensity [ Time Frame: Day 2 ]
    Light transimssion agregometry following exposition to ADP during the acute phase (day2-day 5) and during the chronic phase (day 30-day 60)
  • Maximum aggregation intensity [ Time Frame: Chronic phase (day 30 to day 60) ]
    Light transimssion agregometry following exposition to arachidonic acid during the during the chronic phase (day 30-day 60)


Information By: Hopital Lariboisière

Dates:
Date Received: January 12, 2014
Date Started: January 2013
Date Completion: December 2015
Last Updated: January 15, 2014
Last Verified: January 2014