Clinical Trial: Acute Lung Injury After Allogeneic Transplantation - Diagnosis and Early Treatment

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: A Randomized Clinical Trial on the Use of Early Intermittent Non-Invasive Ventilation in Patients Suffering From Acute Lung Injury After Allogeneic Transplantation

Brief Summary:

Acute lung injury (ALI) is an early complication after allogeneic transplantation causing significant mortality and morbidity. Little is known on early markers and treatment of this complication. Recent data (Hilbert et al.) suggested a beneficial effect of Non-Invasive-Ventilation in ALI-patients immunosuppressed because a many different reasons including stem-cell transplantation.

The investigators study is designed to evaluate early markers of ALI after allogeneic transplantation. In case ALI is documented patients are randomized to either conventional therapy (oxygen-support) or conventional therapy plus intermittent Non-Invasive Ventilation. The hypothesis is that Non-Invasive Ventilation improves outcome of ALI after allogeneic transplantation.

Detailed Summary:
Sponsor: Technische Universität Dresden

Current Primary Outcome:

Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Technische Universität Dresden

Dates:
Date Received: February 26, 2009
Date Started: December 2001
Date Completion:
Last Updated: February 26, 2009
Last Verified: February 2009