Clinical Trial: Changes in Alveolar Macrophage Function During Acute Lung Injury
Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Observational
Official Title: Changes in Alveolar Macrophage Function During Acute Lung Injury
Brief Summary: In this study, the investigators aim to observe the change in alveolar macrophage function during acute lung injury.
Detailed Summary: Alveolar macrophages are tissue-resident or recruited cells with key functions in recognition of pathogens, initiation of host defensive ang protective inflammation,and in clearance of pathogens from the airways. However, macrophages are also responsible for efficient clearance of apoptotic neutrophils, termed efferocytosis, which is a prerequisite for the timely resolution of inflammation. In this study, the investigators aim to observe the change in alveolar macrophage function during acute lung injury.
Sponsor: West China Hospital
Current Primary Outcome: alveolar macrophages (AMs) phagocytic index [ Time Frame: 7 days after admission ]
Original Primary Outcome: AM phagocytic index [ Time Frame: 7 days after admission ]
Current Secondary Outcome: 30 days mortality [ Time Frame: 30 days after admission ]
Original Secondary Outcome: Same as current
Information By: West China Hospital
Dates:
Date Received: February 11, 2016
Date Started: September 2016
Date Completion: August 2018
Last Updated: February 26, 2016
Last Verified: February 2016