Clinical Trial: Discovery of New Early Detection Biomarkers of Acute Respiratory Distress Syndrome

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Observational

Official Title: Discovery of New Early Detection Biomarkers of Acute Respiratory Distress Syndrome

Brief Summary: The goal of this project is to find a series novel biomarkers by differential proteomic techniques that can improve the early diagnosis and develop a more efficient therapy to enhance ARDS patient survival rate.

Detailed Summary: Acute respiratory distress syndrome(ARDS) has a very poor prognosis and high mortality. To improve the early diagnosis of ARDS, there is an urgent need for novel biomarkers of ARDS. The goal of this project is to find a series novel biomarkers by differential proteomic techniques that can improve the early diagnosis and develop a more efficient therapy to enhance ARDS patient survival rate. Clinical data and blood sample were recorded before treatment and after treatment. Acute Physiology And Chronic Health Evaluation III (APACHE III) scores were calculated at enrolment. Studying blood specimens from different period ARDS patients by proteomic analysis. It can provide information on a complex composition of proteins that are differentially expressed, which could be used for discovering high sensitivity and specificity ARDS biomarker.
Sponsor: Xiangya Hospital of Central South University

Current Primary Outcome:

  • Analysis of serum proteins directly by proteomics analysis to identify new biomarkers of ARDS [ Time Frame: baseline ]
  • Analysis of serum proteins directly by proteomics analysis to identify new biomarkers of ARDS [ Time Frame: 1 month ]


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • APACHE III score [ Time Frame: baseline, 1week, 2 weeks ]
  • PaO2/FiO2 ratio [ Time Frame: baseline, day 3, day 5, 1week, 2 weeks ]
  • Mortality or multi-organ failure [ Time Frame: 1 month ]


Original Secondary Outcome: Same as current

Information By: Xiangya Hospital of Central South University

Dates:
Date Received: November 24, 2015
Date Started: January 2016
Date Completion: January 2019
Last Updated: December 5, 2015
Last Verified: December 2015