Clinical Trial: Incidence And Outcome Of Paracentesis Induced Circulatory Dysfunction In Acute-On-Chronic Liver Failure.
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: To Study the Incidence And Outcome Of Paracentesis Induced Circulatory Dysfunction In Acute-On-Chronic Liver Failure Undergoing Less Than 5 Litres Of Ascitic Fluid Tap Wit
Brief Summary:
All consecutive patients admitted in ILBS from MAY 2015 to DECEMBER 2016.ACLF (Acute on chronic Liver Failure). ACLF will be randomize into
Group 1: MVP (Modest Volume Paracentesis) OF Less than 5 liters with IV albumin at a dose 8 gms/L of ascitic fluid
Group 2: MVP (Modest Volume Paracentesis) of Less than 5 liters without albumin
Detailed Summary:
Sponsor: Institute of Liver and Biliary Sciences, India
Current Primary Outcome: Total number of patients develop Circulatory Dysfunction because of paracentesis. [ Time Frame: 1 Year ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Survival [ Time Frame: 28 days ]
- Total number of patients develop hepatorenal Syndrome. [ Time Frame: 1 Year ]
- Total number of patients develop hyponatremia. [ Time Frame: 1 Year ]
- Changes in aldosterone with volume of ascitic fluid tap [ Time Frame: 1 Year ]
- Changes in plasma renin activity [ Time Frame: 1 year ]
Original Secondary Outcome: Same as current
Information By: Institute of Liver and Biliary Sciences, India
Dates:
Date Received: June 4, 2015
Date Started: March 2015
Date Completion: March 2017
Last Updated: January 1, 2017
Last Verified: January 2017
