Clinical Trial: Granulocyte Colony Stimulating Factor(G-CSF) Therapy for Patients With ACLF
Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional
Official Title: To Study the Safety and Efficacy of G-CSF Therapy on the CD 34 Cell Mobilization and Outcome of Patients With ACLF
Brief Summary: The purpose of the study is to determine whether Granulocyte Colony Stimulating factor(G-CSF) therapy is effective in the treatment of patients with Acute on chronic liver failure(ACLF). The investigators hypothesize that ACLF is a disease where severe hepatic impairment is accompanied by impaired hepatic regeneration. BMC mobilization using G-CSF therapy, or G-CSF therapy per se would increase the regenerative capacity of the liver and shall lead to clinical, biochemical and histological improvements in patients with ACLF.
Detailed Summary:
Sponsor: Govind Ballabh Pant Hospital
Current Primary Outcome: mobilization of CD34 cells in the peripheral blood [ Time Frame: 1 month ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- clinical/ biochemical improvement in liver function profile [ Time Frame: 2 months ]
- frequency of multi-organ failure [ Time Frame: 2 months ]
Original Secondary Outcome: Same as current
Information By: Govind Ballabh Pant Hospital
Dates:
Date Received: December 17, 2009
Date Started: December 2008
Date Completion: August 2010
Last Updated: December 18, 2009
Last Verified: December 2009
