Clinical Trial: Spectrum, Profile and Outcome of Infections in Patients With Cirrhosis and/ or Acute on Chronic Liver Failure

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Spectrum, Profile and Outcome of Infections in Patients With Cirrhosis and/ or Acute on Chronic Liver Failure Admitted in Liver Specialty ICU (Intensive Care Unit)- An Obs

Brief Summary: After successful screening diagnosis of cirrhosis and/or acute or chronic liver failure will be made. These patients will undergo detail clinical, biochemical and microbiological examination at baseline. Clinical examination and Biochemical evaluation will be done daily and signs of infection will be noted. Patients will undergo microbiological screening for infection every 48 hours. Patients suspected or diagnosed to be suffering from infections will be treated as per ILBS (Institute of Liver and Biliary Sciences) antibiotic policy. Site and etiology (bacterial and/or fungal) of infections will be noted in all patients at admission in liver specialty ICU (Intensive Care Unit) and during the ICU (Intensive Care Unit) stay. All the patients will be followed until discharge or death in ICU (Intensive Care Unit).

Detailed Summary:
Sponsor: Institute of Liver and Biliary Sciences, India

Current Primary Outcome: Mortality within 1 month during ICU (Intensive Care Unit) stay. [ Time Frame: 30 days ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Number of days stayed in ICU (Intensive Care Unit). [ Time Frame: 30 days ]
  • Risk factors determination in development of multidrug resistance bacteria.Risk factors are defined as Nosocomial infection,Recent Hospitalization, recent antibiotic usage, SBP (spontaneous bacterial peritonitis)prophylaxis, diabetes etc [ Time Frame: 30 days ]
  • Proportion of patients with organ failure. [ Time Frame: 30 days ]


Original Secondary Outcome:

  • Number of days stayed in ICU (Intensive Care Unit). [ Time Frame: 30 days ]
  • Risk factors determination in development of multidrug resistance bacteria.Risk factors are defined as Nosocomial infection,HCA (Health Care Associated)infection,Recent Hospitalization. [ Time Frame: 30 days ]
  • Proportion of patients with organ failure in both groups. [ Time Frame: 30 days ]


Information By: Institute of Liver and Biliary Sciences, India

Dates:
Date Received: April 27, 2013
Date Started: June 2013
Date Completion:
Last Updated: May 23, 2015
Last Verified: November 2014