Clinical Trial: Preoperative Feeding With a Whey Protein Plus Carbohydrate Drink on the Acute Phase Response and Insulin Resistance

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effects of Preoperative Feeding With a Whey Protein Plus Carbohydrate Drink on the Acute Phase Response and Insulin Resistance.

Brief Summary: Prolonged fasting may increase the organic response to trauma. Carbohydrate-based drinks have been tested and they may reduce insulin resistance. No study so far has aimed to examine the possible benefits of whey protein drink in the composition of preoperative drinks.

Detailed Summary:

The patients will be randomized into two groups: the carbohydrate-protein group (CHO-P) and the control group (CO). The patients will reeive a specific drink to their group on the evening prior to surgery and three hours before the operation. The CHO-P group will receive 474 ml (evening drink) or 237 ml (3h prior to operation drink) of a solution containing 14% whey protein (100% lactoalbumin), 86% carbohydrates (45% hydrolyzed corn starch and 55% sucrose) and 0% lipids (Resource® Breeze - Nestlé, São Paulo, Brasil) and the CO group will receive the same volume of water.

Outcome measures On the day of the surgery and on the first postoperative day blood samples will be collected for glucose, insulin, triglycerides, albumin, pre-albumin, CRP, and α-1-acid glycoprotein (α-1-GA) assays. HOMA-IR will be calculated


Sponsor: Federal University of Mato Grosso do Sul

Current Primary Outcome: insulin resistance [ Time Frame: Homa-IR will be assessed in two time points: baseline (2-3 h before operatio) and 24h after operation ]

Insulin resistance will be assessed by Homa-IR


Original Primary Outcome: Same as current

Current Secondary Outcome: acute-phase response [ Time Frame: Assays for the various acute-phase proteins will be done 2-3h before operation and 24 h after the operation ]

Assays for albumin, pre-albumin, C reactive protein and α-1-acid glycoprotein


Original Secondary Outcome: Same as current

Information By: Federal University of Mato Grosso do Sul

Dates:
Date Received: May 10, 2011
Date Started: July 2010
Date Completion:
Last Updated: May 13, 2011
Last Verified: May 2011