Clinical Trial: Acute Phase Reactions and Thrombophilia in Pediatric Patients With Migraine

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Acute Phase Reactions and Thrombophilia in Pediatric Patients With Migraine, Laboratory Investigations in Steady State and During Migraine Attack

Brief Summary: Acute Migraine attacks can be related to vascular or coagulation activation. Previous studies found relative high incidence of prothrombotic events in Migraine. The present study intends to assess the coagulation system and activation in patients with Migraine during steady state phase and at the beginning of attacks and after 72 hours. A control group of patients with another acute neurologic event like convulsions will be also studied. Patients will be at pediatric age and teenagers.

Detailed Summary:
Sponsor: HaEmek Medical Center, Israel

Current Primary Outcome: Proportion of patients with activation of the coagulation system. [ Time Frame: Two years, each patient will be studied at attack onset and after 72 hours. ]

The further analysis will be performed in each patient: Pt, PTT, Platelets, Protein C, S, Antithrombin III, D Dimer, Factor VIII, Factor IX, Von Willebrand Factor and Prothrombin fragments I and II will be analyzed on day one of the crises, after 72 hours and in steady state.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: HaEmek Medical Center, Israel

Dates:
Date Received: September 27, 2011
Date Started: August 2011
Date Completion: December 2016
Last Updated: August 30, 2015
Last Verified: August 2015