Clinical Trial: Cortisol Response to Low Dose Cosyntropin Stimulation Test in the Late Afternoon
Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional
Official Title: Cortisol Response to Low Dose Cosyntropin Stimulation Test in the Late Afternoon
Brief Summary: Previous study showed that afternoon cosyntropin testing was associated with a sevenfold increased likelihood of failing the 1μg test. However, in that study, investigators used a 20.3 cm plastic tube, which might have led to uncompleted cosyntropin delivery. In ther current study investigators will study afternoon 1μg cosyntropin cortisol stimulation using a short 2.5 cm tube.
Detailed Summary:
In earlier studies investigators claimed that subnormal cortisol response using plastic tubes might result from cosyntropin adherence to the tube and loss of the delivered dosage. It was shown that 21.6-58.6% of ACTH dosage had not been recovered when pushed through 20.3 cm plastic tube, and loss of ACTH may be up to 70% when cosyntropin was delivered through a plastic 30 cm scalp vein set.
Moreover, it was previously shown that afternoon cosyntropin testing was associated with a sevenfold increased likelihood of failing the 1μg test. However, in that study, investigators used a 20.3 cm plastic tube, which might have led to uncompleted cosyntropin delivery. In ther current study investigators will study afternoon 1μg cosyntropin cortisol stimulation using a short 2.5 cm tube.
Sponsor: Bnai Zion Medical Center
Current Primary Outcome: Blood cortisol [ Time Frame: one day ]
Original Primary Outcome:
- Blood cortisol [ Time Frame: one year ]Serum cortisol concentrations during intravenous low dose cosyntropin stimulation through short tube.
- Salivary free cortisol [ Time Frame: one year ]Salivary free cortisol concentrations during intravenous low dose cosyntropin stimulation through short tube.
Current Secondary Outcome: Salivary free cortisol [ Time Frame: one day ]
Original Secondary Outcome:
Information By: Bnai Zion Medical Center
Dates:
Date Received: March 3, 2017
Date Started: March 20, 2017
Date Completion: June 1, 2018
Last Updated: March 18, 2017
Last Verified: March 2017