Clinical Trial: Topical Tofacitinib for the Treatment of Alopecia Areata and Its Variants

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Interventional

Official Title: Topical Tofacitinib for the Treatment of Alopecia Areata and Its Variants

Brief Summary: The purpose of the study is to investigate the use of topical tofacitinib to promote hair regrowth in patients with alopecia areata, alopecia totalis, and alopecia universalis.

Detailed Summary: This will be an open label clinical trial. We plan to treat 10 adults with AA (with at least 2 patches of alopecia involving the scalp), AT or AU with tofacitinib ointment for a maximum of 6 months. During treatment, patients will be evaluated every 4 weeks and effectiveness of the medication will be measured by changes in hair growth. Laboratory evaluation will be performed before and during treatment in order to monitor for adverse effects of the medication.
Sponsor: Yale University

Current Primary Outcome: Mean Change in Severity of Alopecia Tool (SALT) Score [ Time Frame: 12 Months ]

SALT score range is from 0 (no hair loss) to 100 (100% hair loss)


Original Primary Outcome: Same as current

Current Secondary Outcome: Hair Regrowth [ Time Frame: 12 Months ]

Clinical photographs will be used to demonstrate presence or absence of hair regrowth.


Original Secondary Outcome: Same as current

Information By: Yale University

Dates:
Date Received: June 21, 2016
Date Started: September 2016
Date Completion: December 2017
Last Updated: December 15, 2016
Last Verified: December 2016