Clinical Trial: Strategies to Reduce Iron Deficiency

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Caring for Those Who Share: Mitigating Iron Deficiency In Regular Blood Donors

Brief Summary:

The prevalence of iron deficiency in blood donors has been demonstrated to be a direct consequence of repeat blood donations. Given the adverse effects of iron deficiency, it is priority to implement programs to remediate iron deficiency issues associated with blood donations. To explore this issue, the study's aims to:

  1. Determine whether regular blood donors provided with accurate information about their iron status and written recommended courses of action will take steps to prevent/mitigate iron deficiency on their own without being given iron supplements by the blood center; and
  2. Determine if two different amounts of iron provided by the blood center will prevent/mitigate iron deficiency in regular blood donors.

To conduct this randomized, placebo controlled study, participant donors will be assigned to one of two arms and followed for a 24 month period. Each subject will provide additional blood samples of 7 ml and 4.5 ml at each study visit for the purpose of tracking hemoglobin (Hgb), ferritin, soluble transferrin receptor (sTfR), and hematology laboratory results.

Under the two study arms, subjects are to be randomized into one of the following five blinded categories:

  • Receive a thank you letter after each blood donation.
  • Receive a letter informing them of their ferritin result at each visit, along with recommendations for blood donation.
  • Receive pills to take daily that contain no iron (a placebo or inert pill).
  • Receive pills to take daily that contain 19 mg of iron (the typical amount in a multivitamin with ir

    Detailed Summary:

    Inclusion Criteria

    • Donors who have donated whole blood or double red cells ≥ 2 times in the last 12 months if female, or, ≥ 3 times in the last 12 months if male.
    • Commitment to meet the donation frequency requirement for the study for two more years, give a blood sample at each visit, and complete baseline and follow-up surveys.

    Exclusion Criteria

    • Subjects < 18 years of age.
    • Subjects taking iron supplements (including multivitamins with iron) up to one month prior to enrollment.
    • Females who are pregnant or plan to become pregnant in the following 2 years.
    • Subjects unwilling to meet the requirements of the study.

    Sponsor: Westat

    Current Primary Outcome: Hemoglobin (HgB) [ Time Frame: Change from baseline in HgB over 2 years ]

    a protein responsible for transporting oxygen in the blood


    Original Primary Outcome: Same as current

    Current Secondary Outcome:

    • Ferritin [ Time Frame: Change from baseline in ferritin over 2 years ]
      a protein that stores iron and releases it when your body needs it
    • Soluble transferrin receptor (sTfR) [ Time Frame: Change from baseline in sTfR over 2 years ]
      a protein receptor that is used as a measure of functional iron status and the investigation of iron deficiency anemia
    • Laboratory Hematology results [ Time Frame: Change from baseline in Laboratory hematology results over 2 years. ]
      Hemoglobin, Hematocrit, Mean Corpuscular Value (MCV), Mean Corpuscular Hemoglobin (MCH)


    Original Secondary Outcome: Same as current

    Information By: Westat

    Dates:
    Date Received: September 10, 2014
    Date Started: June 2011
    Date Completion:
    Last Updated: May 22, 2017
    Last Verified: May 2017