Clinical Trial: Embryo Aneuploidies and Morphokinetics in Ovarian Stimulated and Non Stimulated IVF Cycles

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Observational

Official Title: Embryo Aneuploidies and Morphokinetics in Ovarian Stimulated and Non Stimulated Cycles. An Intrapatient Comparison Using Next Generation Sequencing in Biopsy of Blastocyst

Brief Summary: The purpose of this study is to compare the number of euploid embryos obtained per metaphase II oocyte in unstimulated (modified natural cycles) and stimulated IVF cycles.

Detailed Summary: Effects of ovarian stimulation on human embryo quality is still a subject of study. When natural and stimulated cycles have been compared, no differences have been observed in terms of embryo cleavage capacity, oocyte and embryo aneuploidy rate or incidence of aneuploidy in aborted foetuses. When mild and conventional doses of gonadotropins have been compared, a higher proportion of good morphological quality embryos are observed in the former. On the contrary, we showed that ovarian stimulation does not increase significantly the embryo aneuploidy rate in IVF derived human embryos when unstimulated and stimulated cycles were compared in oocyte donors. In this study, we want to compare the embryo aneuploidy rate between unstimulated and stimulated cycles in infertile patients, subjected to both IVF cycles with blastocyst biopsy and NGS-PGS. A comparison of the morphokinetics will also be performed.
Sponsor: Instituto Valenciano de Infertilidad, IVI VALENCIA

Current Primary Outcome: Comparison of the number of euploid embryos from Metaphase II oocytes in different cohorts of embryos. [ Time Frame: 30 days ]

Number of metaphase II oocyte per euploid embryo in unstimulated and stimulated cycles.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Incidence of embryo aneuploidies in two cohorts of embryos. [ Time Frame: 30 days ]
    Incidence of embryo aneuploidies between the unstimulated and stimulated cycle in the same patient
  • Morphokinetic evaluation of embryos in two different cohorts of embryos. [ Time Frame: 30 days ]
    Morphokinetic evaluation of the embryos obtained in an unstimulated and stimulated cycle


Original Secondary Outcome: Same as current

Information By: Instituto Valenciano de Infertilidad, IVI VALENCIA

Dates:
Date Received: April 10, 2017
Date Started: April 27, 2017
Date Completion: September 2019
Last Updated: April 20, 2017
Last Verified: April 2017