Clinical Trial: Genetic Investigations in Spontaneous Coronary Artery Dissection (SCAD)
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Genetic Investigations in Spontaneous Coronary Artery Dissection (SCAD)
Brief Summary:
The purpose of the research is to identify mutations (defects in the genetic blueprint) that cause spontaneous coronary artery dissection (SCAD), in other words, spontaneous tears in blood vessels that supply the heart.
Some mutations may be inherited (passed on) from a parent without an apparent blood vessel problem while others may develop for the first time in the affected person.
Detailed Summary:
Study question: Do mutations within certain genes cause or confer susceptibility to spontaneous coronary artery dissection (SCAD)?
Specific aims:
- Create a genomic DNA and plasma biobank for individuals diagnosed with SCAD.
- Identify inherited and de novo/new mutations that underlie SCAD.
Long term objective:Discover molecular and cellular mechanisms of SCAD and develop biomarkers to enable prediction and prevention.
The purpose of the research is to identify mutations (defects in the genetic blueprint) that cause tears in blood vessels that supply the heart. Some mutations may be inherited (passed on) from a parent without an apparent blood vessel problem while others may develop for the first time in the affected person. The study includes individuals diagnosed with spontaneous coronary artery dissection and their biological parents.
Adults with SCAD will be identified both retrospectively and prospectively.Confirmation of the diagnosis by review of coronary angiography will be required before proceeding with the informed consent process and blood or saliva sample procurement.
Sponsor: Mayo Clinic
Current Primary Outcome: Identification of one or more gene mutation responsible for SCAD [ Time Frame: By end of study ]
Original Primary Outcome:
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Mayo Clinic
Dates:
Date Received: August 30, 2011
Date Started: May 2011
Date Completion: December 2020
Last Updated: April 1, 2016
Last Verified: April 2016
