Clinical Trial: Prospective Observation for Serial Changes of Acute Intracranial Artery Dissection Using High Resolution MRI

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Prospective Observation for Serial Changes of Acute Intracranial Artery Dissection Using High Resolution MRI

Brief Summary: Intracranial artery disease has been more detected with development of HR-MR. HR-MR can depict vascular wall directly and give us more information beyond the pre-existing imaging modalities such as digital subtraction angiography, magnetic resonance angiography, computed tomography angiography. Hence, HR-MR is considered to become promising imaging modality for intracranial artery disease and many studies have been published recently. However, there was not enough to differentiate various intracranial artery disease such as atherosclerosis, dissection, moyamoya disease, vasculitis, reversible vasoconstriction syndrome. In real clinical arena, intracranial artery disease is too difficult to diagnose and distinguish among the disease. Of the disease, usefulness of HR-MR has been consistently published in the detection and diagnosis of intracranial artery dissection recently. HR-MR seems to be the most important and reliable imaging method in intracranial artery dissection as of now. Therefore, intracranial artery dissection is necessary to study using HR-MR. Intracranial artery dissection is dynamic vascular pathology. The geometric change is the most common among intracranial artery disease. However, there was no report about the geometric change in HR-MR. The investigators acquired retrospective data about the natural course of intracranial artery dissection in HR-MR and are preparing for publishing an article. However, the data is not prospective and not intraindividual comparison. Therefore, reliability is not enough to convince the natural course. If the investigators got prospective and intraindividual data, definite natural course of intracranial artery dissection could be acquired and would be helpful to diagnose the dissection and differentiate from other vascular pathologies. The prospective longitudinal information from this study could guide us as the important map on the confusing HR-MR findings. The protocols for imaging are as follows: initial (optional

Detailed Summary:
Sponsor: Asan Medical Center

Current Primary Outcome:

  • Five proportions (%) of dissection findings [ Time Frame: 12 months ]
    Visual detection based on PACS system by obsevers: Presence or absence of each finding (intimal flap, double lumen, intramural hematoma, aneursymal dilatation, wall enhancement): Proportions (%)= number of patients with presence of each finding/ number of all patients
  • Three diameters (mm) of dissecting arterial segment and contralateral segment [ Time Frame: 12 months ]
    Outer diameter, Inner luminal diameter, Normal diameter (mm) by measured semi-automatic in-house analysis software based on Image J
  • Wall measurement (mm2) of dissecting arterial segment and contralateral segment [ Time Frame: 12 months ]
    Wall area by measured semi-automatic in-house analysis software based on Image J: Wall area (mm2)= Outer wall area - luminal area
  • Remodeling index of dissecting arterial segment and contralateral segment [ Time Frame: 12 months ]
    Remodeling index= outer wall area of dissection segment / [(outer wall area of proximal normal looking segment + outer wall area of distal normal looking segment)/2]
  • Extent (mm) of dissecting arterial segment and contralateral segment [ Time Frame: 12 months ]
    Length (mm) on curved multiplanar reconstructed images by measured semi-automatic in-house analysis software based on Image J


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Asan Medical Center

Dates:
Date Received: September 7, 2016
Date Started: April 2016
Date Completion: December 2018
Last Updated: September 22, 2016
Last Verified: September 2016