Clinical Trial: Effect of Intraoperative Dexmedetomidine on Lung

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Double-blind Randomized Clinical Trial

Brief Summary: Dexmedetomidine has been known to protect the lung against inflammation and oxidative stress in diverse clinical settings. The investigators aimed to investigate the lung protective effect of dexmedetomidine in patients undergoing thoracic aortic surgery with hypothermic circulatory arrest, which is associated with systemic inflammatory response, and oxidative stress.

Detailed Summary: Patients will be divided into 2 groups; dexmedetomidine group and control group. Dexmedetomidine group will receive dexmedetomidine during and after thoracic artery surgery. And control group will receive the same amount of normal saline instead. Analyzing patients lung function and serum factors, which indicates the degree of systemic inflammatory responses and oxidative stress, The investigators will investigate the protective effect of dexmedetomidine on lung.
Sponsor: Gangnam Severance Hospital

Current Primary Outcome:

  • Changes of lung oxygenation from baseline to 24 hr after reperfusion [ Time Frame: after induction of anesthesia / after reperfusion 1hr / after reperfusion 6hr / after reperfusion 12hr / after reperfusion 24hr ]
    Lung oxygenation will be assessed by arterial blood gas analysis
  • Changes of lung compliance from baseline to 24 hr after reperfusion [ Time Frame: after induction of anesthesia / after reperfusion 1hr / after reperfusion 6hr / after reperfusion 12hr / after reperfusion 24hr ]
    Lung compliance will be displayed on the ventilator


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Gangnam Severance Hospital

Dates:
Date Received: January 19, 2016
Date Started: February 2016
Date Completion: December 2018
Last Updated: February 5, 2016
Last Verified: February 2016