Clinical Trial: Steroids and Antiphospholipid Syndrome- Related Pregnancy Loss

Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Randomised Controlled Trial of Low Dose Steroid +Aspirin +Heparin Versus Aspirin+Heparin Amongst Pregnant Women With APS

Brief Summary: Does the addition of steroids during the first trimester to the standard aspirin + heparin treatment reduce the miscarriage rates in women with antiphospholipid antibodies and recurrent first trimester miscarriage in those who had an unsuccessful pregnancy with aspirin + heparin?

Detailed Summary: Over the last decade, the APS has emerged as most important treatable cause of recurrent miscarriages. The pathogenesis of fetal loss in this condition is still remains obscure. Despite the success of aspirin + heparin treatment, some pregnant women with APS repeatedly miscarry even on treatment. The trial is designed to determine if addition of steroids has an success in these women. This is in view of recent in vitro data from our unit reporting that there is an increase decidual cytokine response in APS positive women.
Sponsor: Imperial College London

Current Primary Outcome: Successful pregnancy outcome

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Imperial College London

Dates:
Date Received: September 13, 2005
Date Started: October 2005
Date Completion:
Last Updated: September 13, 2005
Last Verified: September 2005