Clinical Trial: Preconceptional Thromboprophylaxis in Recurrent PREGNANCY LOSSES Caused by Antiphospholipid Syndrome

Study Status: Not yet recruiting
Recruit Status: Unknown status
Study Type: Observational

Official Title: A Randomized Clinical Trial of Using Preconceptional Enoxaparin AND Low Dose Aspirin 81mg in Patient With Antiphospholipid Syndrome(APS)

Brief Summary: Preconceptional use of low molecular weight heparin (enoxaparin) and aspirin in patient with recurrent miscarriages with positive anti phospholipid antibodies increase the implantation rate and the duration of pregnancy with low complications to the mother and the baby.

Detailed Summary: Preconceptional heparin during follicular or luteal phase,improves the implantation rate by increasing the blood flow and increasing the implantation factors,also decreasing the pregnancy complication resulting from Antiphospholipid Syndrome (APS).
Sponsor: Woman's Health University Hospital, Egypt

Current Primary Outcome: Pregnancy continuation beyond twelve weeks gestation [ Time Frame: ONE YEAR ]

giving low molecular weight heparin (enoxaparin) and 81 mg aspirin in patients with positive anti phospholipid antibodies with history of recurrent miscarriages or intrauterine fetal deaths in the preconceptional period one month before pregnancy with follow up as regarding the clinical pregnancy rate,the rate of continuation of pregnancy beyond 28 weeks gestation and the complications related to long term use of heparin and the severity of complication of APS in comparison to the traditional use of anticoagulant after documentation of the fetal heart rate


Original Primary Outcome: Pregnancy continuation beyond twelve weeks gestation [ Time Frame: ONE YEAR ]

giving low molecular weight heparin in patients with positive anti phospholipid antibodies with history of recurrent miscarriages or intrauterine fetal deaths in the preconceptional period one month before pregnancy with follow up as regarding the clinical pregnancy rate,the rate of continuation of pregnancy beyond 28 weeks gestation and the complications related to long term use of heparin and the severity of complication of APS in comparison to the traditional use of anticoagulant after documentation of the fetal heart rate


Current Secondary Outcome:

Original Secondary Outcome:

Information By: Woman's Health University Hospital, Egypt

Dates:
Date Received: July 25, 2012
Date Started: March 2012
Date Completion: June 2014
Last Updated: June 20, 2014
Last Verified: March 2012