Clinical Trial: Effectiveness of Garlic Oil in the Treatment of Arsenical Palmer Keratosis

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effectiveness of Garlic Oil in the Treatment of Arsenical Palmer Keratosis

Brief Summary: Twenty patients of mild to moderate degree of arsenical palmer keratosis will be treated with garlic oil capsule orally for 12 weeks to examine its effectiveness in reducing body arsenic load and clinical symptoms. Similar treatment with similar number of arsenic exposed controls and healthy volunteers will be included for comparison.

Detailed Summary:

Thousands of Bangladeshi are suffering from arsenic-induced keratosis affecting palms and soles. Palmer keratosis, particularly in young female, affects the socioeconomic condition. Till today there is no effective treatment.

Twenty patients of mild to moderate degree of arsenical palmer keratosis will be treated with garlic oil in soft capsule (10 mg/day) orally for 12 weeks. Similar treatment will be given to 20 arsenic exposed controls and 20 healthy volunteers for comparison. The aim of this study is to examine the effectiveness of oral administration of garlic oil to reduce body arsenic load and clinical symptoms of arsenical palmer keratosis.


Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Current Primary Outcome: Change in the clinical symptom of keratosis in palm [ Time Frame: 0 week (baseline) to 12 weeks (end) ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Change in biochemical parameters (blood sugar, cholesterol and transaminase) after treatment [ Time Frame: 0 week (baseline), 12 weeks (end) ]
  • Adverse effects following treament [ Time Frame: 0 week (baseline), 12 weeks (end) ]
  • Change in the amount of arsenic in nail [ Time Frame: 0 week (baseline), 20 weeks (end) ]


Original Secondary Outcome: Same as current

Information By: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Dates:
Date Received: December 11, 2012
Date Started: October 2011
Date Completion:
Last Updated: December 11, 2012
Last Verified: December 2012