Clinical Trial: High Omega-3/Low Omega-6 Treatment Diet for Aspirin-exacerbated Respiratory Disease (AERD)
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: A Pilot Study of the Effectiveness of a High Omega-3/Low Omega-6 Treatment Diet for Treating Aspirin-exacerbated Respiratory Disease
Brief Summary: The purpose of this trial is to test the hypothesis that a treatment diet low in omega-6 fatty acids and high in omega-3 fatty acids can cause improvement in asthma symptoms, nasal symptoms, and pulmonary function in patients with aspirin-exacerbated respiratory disease (AERD).
Detailed Summary:
Sponsor: Brigham and Women's Hospital
Current Primary Outcome:
- Change in urinary leukotriene E4 levels [ Time Frame: 2 weeks and 4 weeks ]
- Change in serum leukotriene B4 levels [ Time Frame: 2 weeks and 4 weeks ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Change in asthma control questionnaire score [ Time Frame: Baseline, 2 weeks, and 4 weeks ]
- Change in Sino-Nasal Outcome Test-22 (SNOT-22) score [ Time Frame: Baseline, 2 weeks, and 4 weeks ]
- Change in forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and FEV1/FVC [ Time Frame: Baseline, two weeks, and four weeks ]
Original Secondary Outcome: Same as current
Information By: Brigham and Women's Hospital
Dates:
Date Received: February 14, 2014
Date Started: March 2014
Date Completion:
Last Updated: September 28, 2016
Last Verified: September 2016
