Clinical Trial: Incidence of Bacteremia Following Argon Plasma Coagulation in Patients With Endobronchial Lesions

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Incidence of Bacteremia Following Argon Plasma Coagulation in Patients With Endobronchial Lesions

Brief Summary: Incidence of Bacteremia Following Argon Plasma Coagulation in Patients with Endobronchial Lesions

Detailed Summary:

Bacteremia is a well-recognized invasive medical condition. In most cases, it is a transient phenomenon without clinical consequences. In certain patients, such as those with structural cardiac abnormalities, it may lead to the development of infectious endocarditis. According to an American Heart Association statement, routine endocarditis prophylaxis is indicated prior to invasive procedures with relatively high bacteremia rates, such as dental care,certain types of catheterization and rigid bronchoscopy [1].Fibreoptic bronchoscopy, with or without biopsy is not included in this list due to a very low bacteremia rate [1].This even applies to particularly high risk patients with prosthetic valve or previous endocarditis. Yigla et al. assessed the incidence of bacteremia following bronchoscopy and found 6.5% of bacteremia rate. (2) Recently, Steinfort et al. assessed the bacteremia rate following endobronchial ultrasound and found 7% of bacteremia rate following the procedure. All bacterial isolates were typical oropharyngeal commensal organisms. The transbronchial needle aspiration washing culture was positive in 35% of the patients. However, none of the bacteremic patients had clinical features suggestive of infection and no complications were seen among the cohort. (3) No data are available, however about the bacteremic rate following interventional bronchoscopy for endobronchial obstruction and advance lung carcinoma. In these cases, palliative setting of alleviating central airway obstruction, laser resection, electrocautery, argon plasma coagulation and stenting are techniques that can provide immediate relief.

Argon plasma coagulation (APC) is uses ionize argon gas jet flow to conduct electrons allowing a noncontact mode of treatment (lightning effect). (4, 5) APC has been popular in gastrointestinal endoscopy for superficial coagulation of large mucosal surfaces.
Sponsor: Meir Medical Center

Current Primary Outcome: The bacteremic rate following APC in patients with endobronchial involvment. [ Time Frame: Two years ]

Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Meir Medical Center

Dates:
Date Received: August 8, 2010
Date Started: October 2010
Date Completion:
Last Updated: March 12, 2013
Last Verified: March 2012