Clinical Trial: Vitamin d Levels in Children With Bacterial Meningitis

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Association of Serum 25-hydroxyvitamin D Levels and Outcomes in Children With Bacterial Meningitis

Brief Summary: The purpose of this study is to determine whether deficiency of Vitamin D has association with outcomes of children with bacterial meningitis.

Detailed Summary:

Vitamin D deficiency has been proved in serious diseases patients, including patients in shock, however, few study have been done about association between deficiency of Vitamin D and outcomes of children with bacterial meningitis.

in our study, we will observe incidence of complication and severity of complication between patients who have different Vitamin D status.


Sponsor: Gang Liu

Current Primary Outcome: vitamin d level change [ Time Frame: change in serum vitamin d level from baseline to 28 days after initial hospitalization ]

Serum vitamin d level will be detected in the first day of hospitalization and twenty-eighth day of hospitalization, no vitamin d supplementation during this time


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Clinical assessment of disease severity with Glasgow score [ Time Frame: 1 day ]
    Disease severity will be assessed with Glasgow score in the first day of hospitalization
  • Clinical assessment of disease severity with Glasgow score [ Time Frame: 7 day ]
    Disease severity will be assessed with Glasgow score in the seventh day of hospitalization
  • Clinical assessment of disease severity with Glasgow score [ Time Frame: 28 day ]
    Disease severity will be assessed with Glasgow score in the twenty-eighth day of hospitalization
  • Clinical assessment of disease severity with pediatric critical illness score [ Time Frame: 1 day ]
    Disease severity will be assessed with pediatric critical illness score in the first day of hospitalization
  • Clinical assessment of disease severity with pediatric critical illness score [ Time Frame: 7 day ]
    Disease severity will be assessed with pediatric critical illness score in the seventh day of hospitalization
  • Clinical assessment of disease severity with pediatric critical illness score [ Time Frame: 28 day ]
    Disease severity will be assessed with pediatric critical illness score in the twenty-eighth day of hospitalization
  • Clinical assessment of disease severity with cerebrospinal fluid examination [ Time Frame: 1 day ]
    Cerebrospinal fluid examination including white blood cell count, protein concentration and glucose concentration in cerebrospinal fluid
  • Clinical assessment of disease severity with cerebrospinal fluid examination [ Time Frame: 7 day ]
    Cerebrospinal fluid examination including white blood cell count, protein concentration and glucose concentration in cerebrospinal fluid
  • Clinical assessment of disease severity with cerebrospinal fluid examination [ Time Frame: 28 day ]
    Cerebrospinal fluid examination including white blood cell count, protein concentration and glucose concentration in cerebrospinal fluid
  • Assessment of complications [ Time Frame: 1 day ]
    Assessment of complications include whether patients have complications, which kind of complication patients suffered, and whether needing surgical therapy.
  • Assessment of complications [ Time Frame: 7 day ]
    Assessment of complications include whether patients have complications, which kind of complication patients suffered, and whether needing surgical therapy.
  • Assessment of complications [ Time Frame: 28 day ]
    Assessment of complications include whether patients have complications, which kind of complication patients suffered, and whether needing surgical therapy.


Original Secondary Outcome: Same as current

Information By: Beijing Children's Hospital

Dates:
Date Received: March 18, 2015
Date Started: May 2015
Date Completion: June 2016
Last Updated: June 5, 2015
Last Verified: May 2015