Clinical Trial: Cardiac Involvement in Patients With Duchenne/Becker Muscular Dystrophy
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Cardiac Involvement in Patients With Duchenne/Becker Muscular Dystrophy
Brief Summary: This study evaluates the function of the heart in young patients with muscular dystrophy type Duchenne or Becker. Participants have their hearts examined at regular intervals by ultrasound (echocardiography) and cardiac magnetic resonance imaging.
Detailed Summary: Muscular dystrophy leads to progressive loss of function in all muscles during childhood and adolescence, including the heart. The usual method to evaluate the heart is echocardiography, emphasizing few parameters. Cardiac magnetic resonance imaging is not as widely available as echocardiography, but early changes can be detected before they become visible on echocardiography. In this study, the investigators compare the methods of measuring heart function in order to find the best measurements for follow up and to see how fast the degenerative changes occur in the hearts of patients with muscular dystrophy.
Sponsor: University Children's Hospital, Zurich
Current Primary Outcome: Left ventricular ejection fraction [ Time Frame: 3 years per patient ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Quantification of fibrosis by LGE/T1 mapping [ Time Frame: 3 years per patient ]
- NT-proBNP [ Time Frame: 3 years per patient ]
Original Secondary Outcome: Same as current
Information By: University Children's Hospital, Zurich
Dates:
Date Received: June 10, 2015
Date Started: May 2015
Date Completion: April 2020
Last Updated: October 12, 2016
Last Verified: October 2016
