Clinical Trial: Novel Intervention for Amphetamine-type Stimulants Addiction

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: Glutamate and γ-aminobutyric Acid (GABA) Deficits in Prefrontal-striatal Circuits: it's Role in Amphetamine-type Stimulants Addiction and Novel Intervention

Brief Summary: The motivational-cognitive psychotherapy and repetitive transcranial magnetic stimulation (rTMS) will be used to treat amphetamine-type stimulant (ATS) addiction.

Detailed Summary: The Glutamate and GABA deficits in prefrontal-striatal circuits play a vital role in ATS addiction and relapse, and proposed motivational-cognitive psychotherapy and repetitive transcranial magnetic stimulation (rTMS) as two novel interventions. Focused on evaluating Glutamate/GABA functions in prefrontal-striatal circuits, neuropsychological tests, biochemical tests, magnetic resonance spectroscopy (MRS) and functional MRI will be used to investigate the neurobiological mechanism of ATS addiction and relapse. These methods will also be used to evaluate the efficacy of the two novel intervention and investigate the mechanisms. The study will be very helpful to develop novel interventions in clinical practice and decrease ATS-related harm for both the patients and their families.
Sponsor: Shanghai Mental Health Center

Current Primary Outcome: Change from Baseline Craving for ATS assessed by Visual Analog Scales (VAS) at 12 months [ Time Frame: Baseline and 12 months ]

evaluate all participants' craving for ATS by Visual Analog Scales (VAS)


Original Primary Outcome: Change from Baseline Craving for ATS assessed by Visual Analog Scales (VAS) at 12 months [ Time Frame: 12 months ]

evaluate all participants' craving for ATS by Visual Analog Scales (VAS)


Current Secondary Outcome:

  • Number of participants who relapse [ Time Frame: 12 months ]
    Follow up with patients after discharge, evaluate number of participants who relapse
  • Depression status assessed by Patient Health Questionnaire-9(PHQ-9) [ Time Frame: 12 months ]
    evaluate all participants' depression status by Patient Health Questionnaire-9(PHQ-9)
  • Anxiety status assessed by Generalized Anxiety Disorder Screener (GAD-7) [ Time Frame: 12 months ]
    evaluate all participants' anxiety status by Generalized Anxiety Disorder Screener (GAD-7)
  • Cognitive function assessed by CogState Battery (CSB) [ Time Frame: 12 months ]
    evaluate all participants' cognitive function by the computerized CogState Battery (CSB) Chinese version
  • Response inhibition function assessed by stop signal reaction time task(SSRT) [ Time Frame: 12 months ]
    evaluate all participants' response inhibition function by stop signal reaction time task(SSRT)


Original Secondary Outcome: Same as current

Information By: Shanghai Mental Health Center

Dates:
Date Received: March 7, 2016
Date Started: June 2016
Date Completion: December 2019
Last Updated: March 28, 2016
Last Verified: March 2016