Clinical Trial: Evaluation of Immune Function in Biliary Atresia Children With Prolonged Jaundice

Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Observational

Official Title: Impaired T-Lymphocyte Proliferative Function in Biliary Atresia Children With Prolonged Jaundice

Brief Summary: Null hypothesis of this study: Biliary atresia patients with cholestatic jaundice do not have systemic immunity defect.

Detailed Summary: Biliary atresia patients with cholestatic jaundice were noted to have increased incidence of infectious complications. Previous animal models of bile duct ligation with acute jaundice ever demonstrated impairment of both humoral and cellular immune function. We performed the immunity study in biliary atresia patients due to the lack of comprehensive systemic immunity study in pediatric cholestatic model. Systemic humoral immunity (total serum IgG, IgA, IgM, C3 and C4), specific cellular immunity (lymphocyte classification, mitogen response, cytokines level after PHA stimulation test), and non-specific cellular immunity (absolute neutrophil count, PMN CD11b/CD18 expression level, PMN superoxide release function, and PMN phagocytosis function) were tested. Association with serum bilirubin level, nutritional status and blood biochemical values were tested to see the relation between systemic immune function and cholestatic jaundice.
Sponsor: National Taiwan University Hospital

Current Primary Outcome:

Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: National Taiwan University Hospital

Dates:
Date Received: September 9, 2005
Date Started: April 2004
Date Completion:
Last Updated: September 9, 2005
Last Verified: June 2005