Clinical Trial: Biotin Status in Pregnancy

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Biotin Status in Pregnancy

Brief Summary: The purpose of this study is to estimate the number of pregnant women who, during pregnancy, have low levels of the vitamin biotin. The hypothesis of this study is that a large number of pregnant women will have low biotin levels. This information will be used to later determine if low biotin levels during pregnancy cause certain birth defects.

Detailed Summary:
Sponsor: University of Arkansas

Current Primary Outcome: Lymphocyte propionyl-CoA carboxylase (PCC) activities [ Time Frame: 2-3 months ]

Original Primary Outcome: Lymphocyte PCC activities [ Time Frame: at start and end of intervention phase ]

Current Secondary Outcome:

  • Urinary biotin excretion [ Time Frame: 2-3 months ]
  • Urinary 3-hydroxyisovaleric acid (3HIA) excretion [ Time Frame: 2-3 months ]
  • Other biotin-related indicators in urine and blood [ Time Frame: 2-3 months ]


Original Secondary Outcome:

  • Urinary biotin excretion [ Time Frame: at start and end of intervention phase ]
  • Urinary 3HIA excretion [ Time Frame: at start and end of intervention phase ]


Information By: University of Arkansas

Dates:
Date Received: May 6, 2009
Date Started: August 2009
Date Completion:
Last Updated: February 26, 2015
Last Verified: February 2015