Clinical Trial: Comparative Study in the Efficacy of Topical Besifloxocin With Erythromycin for the Management of Acute Blepharitis

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: A Comparative Study in the Clinical and Microbial Efficacy of Topical Besifloxocin Ophthalmic Suspension 0.6% With Erythromycin Ophthalmic Ointment 0.5% BID for the Management of Acute This is a pilot project involving thirty patients with a specific form of inflammtion of the lids called anterior blepharitis. The patients are graded for their signs a symptoms and then randomized to receive either topical Besifloxocin or Erythromycin in addition to standard lid hygiene measures. All patients have cultures of their eyelids performed prior to initiating therapy and are followed for four weeks. The antibiotics are used for two weeks following which repeat cultures of the lids are obtained. The patients are followed for one additional week to ensure that there is no recurrence of their symptoms once the antibiotics are discontinued.

Only adult patients (age 18-100)and women who are not of child bearing potential are included in this study. Then patients have to have symptoms and signs of the disease, blepharitis. Patient who are on unstable antibiotic or steroid regimens and those who cannot discontinue contact lens use are not included in this study.


Sponsor: John, George, M.D.

Current Primary Outcome: Improvement in Signs and Symptoms of Blepharitis [ Time Frame: Four weeks ]

Signs and symptoms of blepharitis were scored and determined before and after treatment with two different antibiotics


Original Primary Outcome: Same as current

Current Secondary Outcome: Evaluate Improvement of Bacterial Cultures With Two Different Topical Antibiotics [ Time Frame: Three weeks ]

Compare improvement of microbial cultures (greater inhibition of bacterial growth) with the two antibiotics used to treat blepharitis


Original Secondary Outcome: Evaluate Improvement of Bacterial Cultures With Two Different Topical Antibiotics [ Time Frame: Three weeks ]

Compare improvement of microbial cultures with the two antibiotics used to treat blepharitis


Information By: John, George, M.D.

Dates:
Date Received: November 21, 2011
Date Started: August 2011
Date Completion:
Last Updated: November 20, 2013
Last Verified: November 2013