Clinical Trial: Effects of Sevoflurane and Propofol on Light Flashed Evoked Pupillometry

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: The Effects of Sevoflurane and Propofol on Light Flashed Evoked Pupillometry

Brief Summary: This is a study to focus on the feasibility of using a monitor which may signal loss of visual function intraoperatively.

Detailed Summary: The degree of a relative afferent pupillary defect (RAPD) has been correlated with the severity of an eye injury and has been shown to have prognostic significance as an indicator of retinal ischemia. Therefore light flashed evoked pupillometry (LFEP) may serve as a useful indicator of visual function. LFEP's are not known to be sensitive to anesthetics. We will measure LFEP's using different anesthetic techniques to see if there are measurable differences in the latency, amplitude and constriction velocity of the pupillary reflex. Prior to induction of anesthesia, pupillometer readings will be taken in the supine position in both eyes. The patient will be anesthetised using a standard induction technique. For maintenance of anesthesia a remifentanil infusion will be administered and supplemented by either propofol infusion (at 120 and 160 mcg/kg/min)or sevoflurane (at 1.5 and 2.5% end-tidal in random sequence. The patients will receive muscle relaxants as needed. Pupillometry readings will be taken in both eyes after induction, after steady maintenance has been achieved and every 10 minutes for 30 minutes at each drug dose.
Sponsor: Rutgers, The State University of New Jersey

Current Primary Outcome: Measure the pupil response using different anesthetic techniques [ Time Frame: pupillometry measurements will be taken in both eyes after induction of anesthesia ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Measure the pupil response using different anesthetic techniques [ Time Frame: When steady maintenance of anesthesia drug is obtained measure pupillometry response at 10 min ]
  • Measure the pupil response using different anesthetic techniques [ Time Frame: When steady maintenance of anesthesia drug is obtaines measure pupillometry response at 20 minutes ]
  • Measure the pupil response using different anesthetic technique [ Time Frame: When steady maintenance of anesthesia drug is obtained measure pu[illometry response at 30 minutes. ]


Original Secondary Outcome: Same as current

Information By: Rutgers, The State University of New Jersey

Dates:
Date Received: April 1, 2009
Date Started: August 2007
Date Completion:
Last Updated: April 23, 2015
Last Verified: August 2013