Clinical Trial: Impact of Antibiotic Treatment of Group A Streptococcal Blistering Distal Dactylitis in Children

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Impact of Antibiotic Treatment of Group A Streptococcal Blistering Distal Dactylitis in Children

Brief Summary: Single-center prospective study to assess the clinical course of group A streptococcal blistering distal dactylitis in children after antibiotic treatment.

Detailed Summary:

Blistering distal dactylitis are very common in children. About 60% are caused by Staphylococcus aureus and some are caused by Group A Streptococcus (GAS) or Streptococcus pyogenes. While these forms have been known for fifty years, few publications are interested in it. Some studies have confirmed that a single antibiotic treatment against the SGA allows the healing of these dactylitis but few surgical teams have adopted this strategy. As all streptococcal infections, they face the risk of acute complications (septicemia, streptococcal toxic shock, etc.) or late (post-streptococcal glomerulonephritis, acute rheumatic fever, etc.). The involvement of the SGA in these dactylitis is easy to demonstrate through the use of rapid GAS test already widely used in other GAS infections (tonsillitis, scarlet fever, streptococcal perianal infections).

This study aims to assess the clinical course of positive GAS test blistering distal dactylitis in children after antibiotic treatment.


Sponsor: Camille JUNG

Current Primary Outcome: Rate healed blistering distal dactylitis with positive GAS test after 10 days of antibiotherapy directed against streptococcus pyogenes [ Time Frame: 10 days ]

The main objective of this study is to evaluate the effectiveness of antibiotic treatment only if paronychia subungual child collected or not collected with a in distal blistering dactylitis with positive GAS test


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Frequency of distal blistering dactylitis with positive GAS test in children [ Time Frame: 18 months ]
  • Frequency of collected distal blistering dactylitis with positive GAS test in children [ Time Frame: 18 months ]
  • Frequency of germs involved in distal blistering dactylitis after pus culture in children [ Time Frame: 18 months ]
  • Sensitivity of GAS test compared to pus culture [ Time Frame: 18 months ]
    Describe the sensitivity of GAS test in distal blistering dactylitis according to different age groups.
  • Specificity of GAS test compared to pus culture [ Time Frame: 18 months ]
    Describe the specificity of GAS test in distal blistering dactylitis according to different age groups.
  • Correlation between GAS test and pus culture in different age groups [ Time Frame: 18 months ]
  • Number of General anesthesia avoided by use of antibiotics treatment instead of surgical procedure in case of collected distal blistering dactylitis [ Time Frame: 18 months ]
  • Number of surgical procedures avoided by use of antibiotics treatment instead of surgical procedure in case of collected distal blistering dactylitis [ Time Frame: 18 months ]
  • Comparison between the cost of antibiotics versus surgical or local treatments of positive GAS test distal blistering dactylitis in children [ Time Frame: 18 months ]
    Evaluate the medical and economic impact of the single antibiotic treatment of distal blistering dactylitis with positive GAS test
  • Rate of healed collected distal blistering dactylitis with positive GAS test after antibiotic treatment [ Time Frame: 18 months ]
  • Number of Nail dystrophy at 3 months of follow-up [ Time Frame: 3 months ]


Original Secondary Outcome: Same as current

Information By: Centre Hospitalier Intercommunal Creteil

Dates:
Date Received: November 25, 2015
Date Started: November 2015
Date Completion: December 2017
Last Updated: June 15, 2016
Last Verified: June 2016