Clinical Trial: Multidrug Blister Pack Study

Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional

Official Title: Electronic Multidrug Blister Packs to Improve Clinical and Humanistic Outcomes in Patients After Hospital Discharge

Brief Summary: The purpose of this study is to determine the benefit of patients using a multidrug blister packs after discharged from an university hospital to their homes.

Detailed Summary: Typical adherence rates for oral prescription medications are approximately 50-76%. Insufficient adherence causes an increase in morbidity, mortality, and costs, and decreases quality of life of patients. Multidrug blister packs are recommended to improve adherence and are widely used in Switzerland. However, evidence is poor and patient-relevant endpoints are seldom measured. This study was designed to compare patient-relevant outcomes in patients with medication repackaged in multidrug blister packs versus patients with medication dispensed in commercially available packages. Adherence of the intervention group will be monitored electronically and feedback will be given to the patients. The intervention will take place in a study pharmacy. Follow-up visits will take place at the study pharmacy at 3, 6, and 12 months for all patients. Study duration will be 12 months.
Sponsor: Kurt Hersberger

Current Primary Outcome:

  • Time to rehospitalisation + time to major therapy adjustment [ Time Frame: 12 months ]
    The outcome measure will be assessed at 3, 6, and 12 months.
  • Medication Possession Ratio [ Time Frame: 12 months ]
    MPR will be assessed at 3, 6, and 12 months.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Timing and taking adherence according to the electronic monitoring system and through patient self report [ Time Frame: 12 months ]
    Electronic monitoring will be continuous over 12 months. Patient self report will be assessed at 3, 6, and 12 months.
  • Quality of life [ Time Frame: 12 months ]
    Quality of life will be assessed at 3, 6, and 12 months.
  • Patient satisfaction [ Time Frame: 12 months ]


Original Secondary Outcome: Same as current

Information By: University Hospital, Basel, Switzerland

Dates:
Date Received: November 2, 2012
Date Started: January 2013
Date Completion:
Last Updated: April 8, 2015
Last Verified: April 2015