Clinical Trial: Use of Proteomics for the Diagnosis of a Platelet-related Bleeding Disorder
Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional
Official Title: Use of Proteomics for the Diagnosis of a Platelet-related Bleeding Disorder
Brief Summary: The goal of this study is to identify the platelet defect responsible for the bleeding in families from our inherited platelet disorders Israeli-Palestinian registry. The investigators plan to characterize platelet proteome expression after removing high abundance proteins. The investigators will compare the proteome of sick and healthy members of families with inherited platelet disorders, and identify and validate structural proteins, signaling cascades and biomarkers for detection and diagnosis of unknown platelet disorders. The investigators expect to discover new key findings that allow better understanding of human platelet function and allow better diagnosis and treatment of patients with inherited platelet function disorders.
Detailed Summary:
Sponsor: Hadassah Medical Organization
Current Primary Outcome: Levels of detectable platelet proteins [ Time Frame: 2014-2015 (1 year) ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Changes in protein expression from sick and healthy platelets [ Time Frame: 2015-2019 (4 years) ]
Original Secondary Outcome: Same as current
Information By: Hadassah Medical Organization
Dates:
Date Received: March 20, 2014
Date Started: February 2017
Date Completion:
Last Updated: March 23, 2016
Last Verified: February 2016