Clinical Trial: The Application of Personalized Titanium Plate in the Bone Tumors Around the Knee

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Personalized Titanium Plate Improves Clinical Outcome in Microwave Ablation of Bone Tumors Around the Knee

Brief Summary: Microwave ablation of bone tumors is time-consuming and usually results in postoperative fractures. Hence the investigators designed and fabricated a titanium plate customized to the patient's bone structures for fixation after the removal of tumorous tissue, to improve the clinical outcomes of microwave ablation.

Detailed Summary: 3D models of tumor-bearing bone segments were constructed by using computed tomography (CT) and magnetic resonance imaging (MRI). The 3D models were used to design the model of personalized titanium plates. The model of the plates was transferred into a numerical control machine for manufacturing the personalized titanium plates by 3D printing technology. The plates were then surgically implanted for reconstruction assistance following microwave-induced hyperthermia to remove the bone tumor. Implementation parameters and knee function were then evaluated.
Sponsor: Guangzhou General Hospital of Guangzhou Military Command

Current Primary Outcome:

  • Musculoskeletal Tumor Society score [ Time Frame: An average of 29 months ]
  • Mean maximum flexion of the knee [ Time Frame: An average of 29 months ]
  • The six degrees of freedom of the gait [ Time Frame: An average of 29 months ]
    including flexion/extension, adduction/abduction, internal/external rotation, anteroposterior translation, distal/lateral translation, medial/lateral translation


Original Primary Outcome: Same as current

Current Secondary Outcome: Mean operation time [ Time Frame: Time when the operation was begun ]

Original Secondary Outcome: Same as current

Information By: Guangzhou General Hospital of Guangzhou Military Command

Dates:
Date Received: August 31, 2016
Date Started: January 2013
Date Completion:
Last Updated: February 9, 2017
Last Verified: February 2017