Clinical Trial: Organ Donation and Hydrocortisone Treatment
Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional
Official Title: Organ Donation and Vasopressor Use: Effects of Hydrocortisone Treatment
Brief Summary: Brain death patients who are selected for organ donation very often suffer from haemodynamic instability. To treat this, high amounts of vasoactive drugs(norepinephrine) may be needed to raise blood pressure. However,norepinephrine may have negative influence on several organs causing reduced blood flow ischemia. Our hypothesis is that hydrocortisone treatment may reduce the amount of vasoactive drugs needed to keep the blood pressure stable in patients selected for organ donation.
Detailed Summary: When patients are treated in the ICU only as possible organ donators they will be assessed for eligibility for the study. Iv hydrocortisone or placebo will be administered every 6 hours. Several hormonal samples will be collected.
Sponsor: Kuopio University Hospital
Current Primary Outcome: dosage and time on norepinephrine treatment [ Time Frame: in ICU ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Hormone levels and number of organs donated [ Time Frame: Hospital treatment ]
Original Secondary Outcome: Same as current
Information By: Kuopio University Hospital
Dates:
Date Received: May 7, 2008
Date Started: May 2008
Date Completion:
Last Updated: April 3, 2015
Last Verified: April 2015