Clinical Trial: Comparison of Physical Activity Level Between Patients With Bronchiectasis and Healthy Subjects

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Comparison of Physical Activity Level Between Patients With Bronchiectasis and Healthy Subjects

Brief Summary:

The purpose of this study is to compare physical activity levels between patients with bronchiectasis and healthy subjects.

We hypothesize that patients with bronchiectasis will have lower levels of physical activity, since physical activity levels is affected by reduced exercise tolerance, severity of disease and other disease related symptoms and conditions.


Detailed Summary:

Physical activity limitation in chronic respiratory diseases is caused by many factors including respiratory, hemodynamic, and peripheral muscle weakness. Bronchiectasis is characterized by irreversible widening of the medium-sized airways, with inflammation, chronic bacterial infection and destruction of the bronchial walls. In addition to pulmonary function worsening, extra pulmonary features such as reduced peripheral muscle endurance can be a significant physical problem which causing a decrease in physical activity levels.

Despite physical activity is considered to be essential for the management of chronic respiratory diseases, there is a lack of scientific study, which compares physical activity levels between patients with bronchiectasis and healthy subjects.

This study will assess physical activity level, exercise capacity, quality of life and peripheral muscle strength in patients with bronchiectasis compared to healthy subjects.


Sponsor: Hacettepe University

Current Primary Outcome:

  • Number of steps on accelerometer [ Time Frame: Seven days ]
    Participants will wear an accelerometer (physical activity monitor) for seven consecutive days.
  • Energy expenditure on activity monitor [ Time Frame: Seven days ]
    Total energy expenditure will be calculated using activity monitor for seven consecutive days
  • Exercise capacity using 6-minute walk test and incremental shuttle walk test [ Time Frame: 1st day (before using device) ]

    6-minute walk test will be performed in a long, straight, enclosed corridor 30 meters in length. Patients are required to walk in their walking speed with standardized instructions. The distance walked by subjects during 6 minutes will be recorded.

    The incremental shuttle walk test will be performed in an enclosed corridor. Patients are required to walk back and forth, turning around two cones placed 9 meters apart making the shuttle distance 10 meters long. Patients will follow the rhythm dictated by the audio signal.

  • Physical activity level using International Physical Activity Questionnaire [ Time Frame: 8th Day ]
  • Peripheral muscle strength test using a hand-held dynamometer [ Time Frame: 1st day (before using device) ]
  • Quality of Life using St. George Respiratory Questionnaire [ Time Frame: 8th Day ]
  • Shortness of breath using the Modified Medical Research Council Dyspnea Scale [ Time Fr

    Original Primary Outcome: Same as current

    Current Secondary Outcome:

    Original Secondary Outcome:

    Information By: Hacettepe University

    Dates:
    Date Received: September 13, 2015
    Date Started: September 2015
    Date Completion: August 2016
    Last Updated: August 15, 2016
    Last Verified: August 2016