Clinical Trial: Pulmonary Rehabilitation in Non Cystic Fibrosis Bronchiectasis
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Pulmonary Rehabilitation in Non Cystic Fibrosis Bronchiectasis
Brief Summary:
The aim of our study is to ascertain whether chest physiotherapy + pulmonary rehabilitation is more efficacious than chest physiotherapy alone. The outcomes that will be used to assess effectiveness are relevant in terms of the direct benefit on the patient's health related quality of life.
PLANNED STUDY: This randomized study will compare 8 weeks chest physiotherapy with 8 weeks chest physiotherapy plus pulmonary rehabilitation.
Detailed Summary:
PLANNED STUDY: This randomized study will compare 8 weeks chest physiotherapy with 8 weeks chest physiotherapy plus pulmonary rehabilitation.
PLAN OF INVESTIGATION: Patients will be recruited from NHS Lothian with 15 randomized to chest physiotherapy and 15 to chest physiotherapy plus pulmonary rehabilitation.
Protocols:
Chest physiotherapy Physiotherapy will be aided using a positive pressure airways device (Acapella) that aids sputum expectoration. They will be asked to do 10 breaths, followed by 3 huffs and a cough. This will be repeated 3 times and repeated twice a day. Expected tiime 10-15 minutes twice daily.
Pulmonary rehabiliation Will be an 8-week programme twice a week in hospital with a third session (unsupervised) at home. It will include both cardiovascular training and upper limb and lower limb strengthening exercises.
Each patient will have a baseline exercise test. Calculation of the patient's 80% peak heart rate will be recorded and then used to ensure that patients are working to this level during the pulmonary rehabilitation cardiovascular sections.
The session will include: 5 minute warm up; 10 minutes treadmill; 10 minutes bicycle; 10 minutes stepper; 10 minutes upper limb and lower limb strengthening exercises; 5 minutes cool down.
Throughout the 8-week programme the resistance and intensity of each activity will be increased as they improve.
Following commencement of their first class they will be provided with a diary for a walking programme at home, which they will do once a week unsupervised.
Sponsor: NHS Lothian
Current Primary Outcome: The primary endpoint of this study is improvement in exercise tolerance from an incremental walk test. [ Time Frame: 8 weeks ]
Original Primary Outcome: Same as current
Current Secondary Outcome: These include pulmonary physiology, 24 hour sputum volume, sputum appearance, health related quality of life and systemic inflammation. [ Time Frame: 8 weeks ]
Original Secondary Outcome: Same as current
Information By: NHS Lothian
Dates:
Date Received: February 19, 2009
Date Started: March 2009
Date Completion:
Last Updated: November 4, 2011
Last Verified: November 2011
