Clinical Trial: Nebulized Hypertonic Saline Treatment in Hospitalized Children With Moderate to Severe Viral Bronchiolitis

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: A Randomized Controlled Trial of Nebulized Hypertonic Saline Treatment in Hospitalized Children With Moderate to Severe Viral Bronchiolitis

Brief Summary: The purpose of this study is planned to investigate whether frequently inhaled hypertonic saline (HS) can relieve symptoms and signs faster than normal saline (NS) and shorten length of stay (LOS) significantly for moderately to severely ill infants with bronchiolitis without apparent adverse effects.

Detailed Summary:

The treatment of bronchiolitis remains largely supportive with mechanical ventilatory support as needed .Other types of treatment remain controversial.We and other researchers have demonstrated that nebulized HS and bronchodilators decreased symptoms and LOS for infants with mild to moderate viral bronchiolitis .All the aforementioned studies used 3 times per day dosing, which is significantly less than the 3 to 6 times per hour regimens often used in children in respiratory distress.Frequently nebulized HS reduced the LOS for infants with moderately severe bronchiolitis.The present study is planned to investigate whether frequently inhaled HS can relieve symptoms and signs faster than NS and shorten LOS significantly for moderately to severely ill infants with bronchiolitis without apparent adverse effects.

PMID: 15266547 PMID: 12576370 PMID: 16599051 PMID: 17719935 PMID: 20014350 PMID: 12475841


Sponsor: Chongqing Medical University

Current Primary Outcome: To determine the efficacy of frequently nebulized HS in moderately to severely ill infants with bronchiolitis [ Time Frame: 1 year ]

Compare the wheezing remission time,Cough remission time,moist crackles disappeared time and the hospital length of stay between HS and NS.


Original Primary Outcome: Same as current

Current Secondary Outcome: To determine the safety of frequently nebulized HS in moderately to severely ill infants with bronchiolitis [ Time Frame: 1 year ]

evaluated for the hoarse voice, vomiting, diarrhea, general condition


Original Secondary Outcome: Same as current

Information By: Chongqing Medical University

Dates:
Date Received: April 23, 2010
Date Started: November 2008
Date Completion:
Last Updated: May 10, 2010
Last Verified: November 2008