Clinical Trial: Extracorporeal Photopheresis in Patients With Bronchiolitis Obliterans Syndrome (BOS) After Lung Transplantation

Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional

Official Title: Extracorporeal Photopheresis in Patients With Bronchiolitis Obliterans Syndrome (BOS) After Lung Transplantation

Brief Summary: Investigation of photopheresis as new therapy regimen in patients with bronchiolitis obliterans syndrome after lung transplantation in a controlled, randomized study

Detailed Summary:

Bronchiolitis obliterans syndrome is the major cause of mortality after lung transplantation. 5 years after lung transplantation about 50% of all patients have this syndrome. There are nearly none therapy options. Besides effective therapy of any gastrooesophageal reflux and an oral medication with azithromycin none further regimens are known. Photopheresis could show in several studies a benefit for patients with gvhd after bone marrow transplantation or for chronic rejection after any other solid organ transplantation. Just little case reports could show beneficial effect in patients with bos after lung transplantation.

This is the first controlled, randomized study with patients with bos after lung transplantation to investigate the effectiveness of this therapy in that patients.

Sponsor: Hannover Medical School

Current Primary Outcome: FEV1 stabilisation [ Time Frame: 6 month ]

Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Hannover Medical School

Dates:
Date Received: July 16, 2007
Date Started: August 2007
Date Completion:
Last Updated: July 25, 2011
Last Verified: May 2008