Clinical Trial: Use of Non Steroidal Antiinflammatory Drugs in Patients With Community Acquired Pneumonia

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Descriptive Analysis of Non Steroidal Antiinflammatory Drugs Use in Patients Diagnosed With Community Acquired Pneumonia

Brief Summary: To investigate exposure to nonsteroidal antiinflammatory drugs (NSAIDs) during outpatient management at the early stage of community-acquired pneumonia (CAP) requiring hospital consultation. Non-interventional observational study.

Detailed Summary: Recent data suggests that such exposure to NSAIDs is associated with delay in CAP diagnosis and antibiotic prescription that influence CAP presention and outcome. The investigators' working hypothesis is that NSAIDs use may mask initial symptoms and delay antimicrobial therapy, thus predisposing to worse outcomes. All patients presenting at one of the three following locations (emergency department, ICU or pneumology ward) with a suspicion of community-acquired pneumonia will be screened for eligibility. Exposure or not to NSAIDs will be investigated. Clinical, biological and radioloigcal features and outcome of CAP will be compared with respect to NSAIDs exposure.
Sponsor: Hôpital Louis Mourier

Current Primary Outcome: binary composite primary endpoint [ Time Frame: 28 days ]

presence or absence of one or more of the following : occurrence of at least one pneumonia-related complication; need for ICU admission; prolonged length of hospital stay.

pneumonia-related complications include: worsening of hypoxemia; need for mechanical ventilation; occurrence or increase of pleural effusion; empyema; occurrence of septic shock;



Original Primary Outcome: Same as current

Current Secondary Outcome:

  • pneumonia severity index [ Time Frame: 2 days ]
    the pneumonia severity index calculated at inclusion will be compared in exposed and non-exposed to NSAID patients
  • CURB score at inclusion [ Time Frame: 2 days ]
    the CURB score (confusion, blood urea nitrogen, respiratory rate and systolic blood pressure) at inclusion will be compared in exposed and non-exposed to NSAID patients
  • duration of antimicrobial therapy [ Time Frame: 28 days ]
  • occurence of a nosocomial infection [ Time Frame: 28 days ]
    occurrence of nosocomial infections (including nosocomial pneumonia, catheter-related blood stream infection, and urinary tract nosocomial infection) will be compared in exposed and non-exposed to NSAID patients
  • 28-day mortality [ Time Frame: 28 days ]


Original Secondary Outcome: Same as current

Information By: Hôpital Louis Mourier

Dates:
Date Received: August 13, 2015
Date Started: November 2013
Date Completion:
Last Updated: February 25, 2016
Last Verified: February 2016