Clinical Trial: Efficacy of Etoricoxib on Peripheral Hyperalgesia

Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional

Official Title: Efficacy of Etoricoxib in Patients With Neuropathic Pain With and Without Peripheral Hyperalgesia - A Prove of Concept Trial

Brief Summary: The purpose of the study is to determine the efficacy of etoricoxib on pain patients. The investigators assume that patients with neuropathic pain will have greater pain relief then patients on placebo.

Detailed Summary: Animal experiments analysing anti-hyperalgesic effects of Coxibs show inconsistent results due to different used dosages and varying different pain models. Theoretical the use of NSAIDs is rational, particularly of Coxibs as a part of the neuropathic pain management. But in the newest topical review, there is no valid information available about the effectiveness of these drugs in human neuropathic pain models or in patients with different underlying mechanism, e.g. with or without hyperalgesia.
Sponsor: Ruhr University of Bochum

Current Primary Outcome: Superior improvement of peripheral hyperalgesia at day six after initiation of Cox-2-inhibiting-medication in comparison to placebo [ Time Frame: 12 month ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Reduction of the average on-going pain [ Time Frame: 12 month ]

Original Secondary Outcome: Same as current

Information By: Ruhr University of Bochum

Dates:
Date Received: March 16, 2010
Date Started: February 2011
Date Completion:
Last Updated: August 23, 2012
Last Verified: August 2012