Clinical Trial: Treatment of Cerebellar Ataxia With Mesenchymal Stem Cells
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Treatment of Cerebellar Ataxia With Mesenchymal Stem Cells
Brief Summary: The study is to investigate the efficacy and safety of allogenous transplantation of adipose-derived mesenchyma stem cells in patients with cerebellar ataxia.
Detailed Summary:
Sponsor: National Yang Ming University
Current Primary Outcome: Safety evaluation [ Time Frame: 12 months ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Alterations in SARA score [ Time Frame: 12 months ]
- Positron emission tomography [ Time Frame: 9 months ]18F-FDG used for the assessment of glucose metabolism in the brain
- Magnetic resonance spectroscopy [ Time Frame: 12 months ]NAA/Cr,Cho/Cr,NAA/Cho ratios to reflect neuronal/cerebral white mater integrity
- Assessment of language and swallowing functions [ Time Frame: 12 months ]changes in levels of severity: normal/slight/mild/moderate/severe
- Evaluation of syncope [ Time Frame: 12 months ]Tilt table test
- Balance test [ Time Frame: 12 months ]
Original Secondary Outcome: Same as current
Information By: National Yang Ming University
Dates:
Date Received: April 10, 2012
Date Started: May 2012
Date Completion:
Last Updated: September 11, 2014
Last Verified: September 2014