Clinical Trial: Effect of Hyperbaric Oxygen on Functional Connectivity in Patients With Cerebral Small Vessel Disease
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: The Effect of Hyperbaric Oxygen on the Functional Connectivity of Resting State Neural Networks in Patients With Cerebral Small Vessel Disease
Brief Summary: Patients will have a Functional MRI before and after 10 hyperbaric Oxygen treatments.
Detailed Summary: Functional MRI studies will be done before and 4-6 weeks after Hyperbaric Oxygen treatment to assess changes in connectivity of resting state neural networks. 10 hyperbaric treatments at 2 atmospheres absolute for 1 hour at pressure will be administered. A review of symptoms and and thorough clinical neurological examination by an experienced neurologist familiar with these studies will be done before and 4-6 weeks after the hyperbaric treatments.
Sponsor: St. Luke's Hospital, Chesterfield, Missouri
Current Primary Outcome: Change in average functional connectivity (fc) within the Default Mode Network and the Dorsal Attention Network will be obtained by resting state network (rsn) functional connectivity (rsnfc) MRI. [ Time Frame: Change in baseline rsnfc before and 4 weeks after hyperbaric oxygen ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: St. Luke's Hospital, Chesterfield, Missouri
Dates:
Date Received: September 5, 2014
Date Started: November 2014
Date Completion: June 1, 2018
Last Updated: May 1, 2017
Last Verified: August 2016