Clinical Trial: Impact of Vaccination on Th2 Immunity in Infancy
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Impact of Vaccination on Th2 Immunity in Infancy
Brief Summary: The purpose of this study is to assess the responses in the immune system of infants after they receive the vaccine against diphtheria, tetanus, and pertussis (DTaP). The investigators will do this by studying the immune cells and allergy responses in the blood prior to and after receipt of the third DTaP vaccine.
Detailed Summary: This is a single-site study of infants who are scheduled to receive their third series (~6 month) vaccinations, as routine care, to investigate whether the diphtheria, tetanus, and pertussis (DTaP) vaccination has an effect on specific immunoglobulin E (IgE) levels to milk, egg, or peanut. Infants will be assigned to one of two groups depending on the infant's sensitization to milk, egg, and peanut.
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Current Primary Outcome: Allergen-specific IgE [ Time Frame: baseline and day 28 ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: National Institute of Allergy and Infectious Diseases (NIAID)
Dates:
Date Received: August 7, 2014
Date Started: August 2014
Date Completion:
Last Updated: November 7, 2016
Last Verified: November 2016