Clinical Trial: Effects of Alpha Lipoic Acid Supplementation in G6PD Deficient Individuals After Acute Exercise
Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional
Official Title: Effects of Alpha Lipoic Acid Supplementation in G6PD Deficient Individuals After Acute Exercise
Brief Summary: The purpose of this study is to investigate the effects of alpha-lipoic acid supplementation on redox status, physiological and biochemical parameters in G6PD deficient individuals after acute exercise.
Detailed Summary:
In a randomized double-blind, crossover design, 12 adult volunteers with G6PD deficiency of both sexes will be supplemented with either 600 mg of alpha-lipoic acid (experimental condition - EC) or placebo (control condition - CC) every day for 4 weeks. Before intervention, all participants will be informed about the study protocol, fill a medical history questionnaire and sign an informed consent form. Moreover, measurements of anthropometric characteristics and physiological parameters, as well as a VO2max test will be performed.
Participants will perform 4 trials of exercise (70% VO2max for 45min and 90% till exhaustion) before and after each condition. Blood samples will be collected before, immediately after and 1 hour after exercise. Moreover, measurements of anthropometric characteristics and physiological parameters will be performed before and after each condition. There will be a washout period of at 4 weeks between conditions.
Sponsor: University of Thessaly
Current Primary Outcome: Change in redox status after exercise [ Time Frame: Before, immediately after and 1 hour after each trial of exercise ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Body composition [ Time Frame: Before and after 4 weeks of alpha-lipoic acid supplementation, before and after 4 weeks of placebo ]Body fat percentage
- Blood pressure [ Time Frame: Before and after 4 weeks of alpha-lipoic acid supplementation, before and after 4 weeks of placebo ]Blood pressure at rest
Original Secondary Outcome: Same as current
Information By: University of Thessaly
Dates:
Date Received: October 12, 2016
Date Started: November 2016
Date Completion: March 2017
Last Updated: October 14, 2016
Last Verified: October 2016