Clinical Trial: Effect of Tonsillectomy on Longterm Renal Outcome of IgA Nephropathy

Study Status: Suspended
Recruit Status: Suspended
Study Type: Interventional

Official Title: Effect of Tonsillectomy on Longterm Renal Outcome of IgA Nephropathy :a Prospective,Randomized,Controlled Study.

Brief Summary: The effect of tonsillectomy therapy on IgA nephropathy is still controversial.Few prospective,randomized investigations have examined how tonsillectomy affects the shortterm and longterm renal outcome of IgA nephropathy.This is A prospective,randomized ,controlled study to explore the longterm effect of tonsillectomy for patients with IgA nephropathy.

Detailed Summary:
Sponsor: Sun Yat-sen University

Current Primary Outcome: Renal survival rate or Deterioration of renal function [ Time Frame: Every 12months for 10 years after tonsillectomy ]

Deterioration of renal function (evidenced by a 50% rise from baseline serum creatinine (SCr) levels, or a 25% decline from baseline estimated glomerular filtration rate (eGFR) levels, or onset of end-stage renal disease or dialysis treatment, or kidney transplantation)after tonsillectomy


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Remission of proteinuria (complete or partial) [ Time Frame: every 3-12months for 10 years after tonsillectomy ]
    The remission rate of proteinuria (include complete or partial remission )
  • Remission of hematuria (complete or partial) [ Time Frame: every 3-12months for 10 years after tonsillectomy ]
    The remission rate of hematuria (include complete or partial remission )
  • Repeat renal biopsy [ Time Frame: the fifth and tenth year after tonsillectomy ]
    reevaluate the renal histological changes by the Lee's glomerular grading
  • Side effects [ Time Frame: every 3-12months for 10 years after tonsillectomy ]
    The shortterm and longterm side effects of tonsillectomy.


Original Secondary Outcome: Same as current

Information By: Sun Yat-sen University

Dates:
Date Received: May 19, 2015
Date Started: March 2011
Date Completion: March 2023
Last Updated: June 10, 2015
Last Verified: June 2015