Clinical Trial: IVIG Treatment for Asthmatic Patients With IgG Subclass Deficiency

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Interventional

Official Title: IVIG Treatment for Asthmatic Patients With IgG Subclass Deficiency

Brief Summary: Immunoglobulin G deficiency subtypes in patients with asthma six months once a month intravenous immunoglobulin (400mg/kg/4weeks) infection in treatment-related effect on reducing the frequency of asthma exacerbations appreciate.

Detailed Summary:

Patients Registration

•It is required to ensure that the patients meet the inclusion criteria for this clinical trial, are free from any items of exclusion criteria, are explained about the participation in the clinical trial along with the informed consent forms.

Procedure

•six months once a month intravenous immunoglobulin (400mg/kg/4weeks)


Sponsor: Ajou University School of Medicine

Current Primary Outcome: Infection rate [ Time Frame: 6months ]

6 months after treatment compared to before treatment 6 months


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • lung funtion [ Time Frame: 6 months ]
    - Lung function (FEV1) compared
  • steroid [ Time Frame: 6 months af ]
    - Systemic steroid dose and the number of uses
  • antibiotic [ Time Frame: 6months ]
    - The frequency and duration of antibiotic
  • asthma syptoms [ Time Frame: 6months ]
    - The frequency of asthma exacerbations
  • Questionnaire [ Time Frame: 6months ]
    - Asthma Quality of Life (AQOL)
  • Questionnair [ Time Frame: 6months ]
    - Asthma control score (K-ACT)
  • IgG subclass [ Time Frame: 6months ]
    - Before and after treatment serum IgG subclass
  • Cytokines [ Time Frame: 6months ]
    - Cytokines serum levels before and after treatment
  • adverse events [ Time Frame: 6months ]
    - The frequency of adverse events


Original Secondary Outcome: Same as current

Information By: Ajou University School of Medicine

Dates:
Date Received: November 11, 2013
Date Started: December 2013
Date Completion: January 2017
Last Updated: April 28, 2016
Last Verified: April 2016