Clinical Trial: Follicular Helper T Cells: Biological Marker and Involvement in the Physiopathology of the IgG4-related Disease

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Follicular Helper T Cells: Biological Marker and Involvement in the Physiopathology of the IgG4-related Disease

Brief Summary:

IgG4-related disease is a rare and very recently identified pathology, whose frequency is certainly underestimated.

The clinical presentation varies among affected organs, and most often, patients have at least three organ damage.

These organs exhibit tissue infiltration mononuclear polymorphic cells with often severe fibrosis progression resulting in a loss of function.

The biomarker, though not specific, is a polyclonal elevated serum IgG4, and histological marker, currently held by several teams, is the presence within the inflammatory infiltrate, of a predominance of IgG4-expressing plasma-cells with a relative plasma-cells IgG4 + / IgG +> 50% on tissue immunostaining.

The investigators project provides a global assessment of T lymphocyte abnormalities and specifically the TFH (Follicular Helper) during this IgG4-related disease compared to so-called groups "control" subjects suffering from Sjogren syndrome or healthy subjects.

Detailed Summary:
Sponsor: Assistance Publique Hopitaux De Marseille

Current Primary Outcome: Proportion of Follicular Helper T cells (CD4 + CXCR5 + ICOShigh) in the blood [ Time Frame: 36 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Assistance Publique Hopitaux De Marseille

Dates:
Date Received: September 2, 2016
Date Started: July 2012
Date Completion:
Last Updated: September 12, 2016
Last Verified: September 2016