Clinical Trial: A New Approach of Neostigmine in Unavoidable Post Operative Ileus

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: A New Approach of Neostigmine in Unavoidable Post Operative Ileus After Surgery

Brief Summary: Postoperative ileus (POI) in the absence of any mechanical obstruction remains a commonly encountered clinical problem.So, this study aimed to show the effective way to decrease the rate of postoperative Ileus (POI).

Detailed Summary: We honestly declare that, the use of parasympathomimetic agents such as neostigmine is not without risk. Patients with underlying bradyarrhythmias or those receiving β-adrenergic antagonists may be more susceptible to neostigmine-induced bradycardia. Similarly, neostigmine increases airway secretions and bronchial reactivity, which may exacerbate active bronchospasm. Recently, a new class of drugs—peripherally acting mu-opioid receptor antagonists—may help enhance multimodal management of POI. Although, the cost benefit of the new class of drugs is debated. It has been suggested that the individual components of multimodal protocols—for example, laparoscopy—may reduce certain post surgical morbidities (including POI) But do not by them prevent POI. Therefore, combinations of strategies with demonstrated effectiveness—early feeding , epidural analgesia, laparoscopic surgery, and use of peripherally acting mu-opioid-receptor antagonists—may help transform the reactive approach to POI into a proactive multimodal paradigm that effectively targets the diverse etiologic factors leading to this common clinical problem.
Sponsor: Baqiyatallah Medical Sciences University

Current Primary Outcome: show the effective way to decrease the rate of postoperative Ileus (POI). [ Time Frame: 6 hours ]

Original Primary Outcome: Same as current

Current Secondary Outcome: abdominal circumference, colonic diameters, and clinical response were again measured. [ Time Frame: 3 hours ]

Original Secondary Outcome: Same as current

Information By: Baqiyatallah Medical Sciences University

Dates:
Date Received: May 12, 2008
Date Started: August 2007
Date Completion:
Last Updated: May 12, 2008
Last Verified: May 2008