Clinical Trial: Oxidant Status and Effect of Antioxidant in Immune Thrombocytopenia

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Evaluation of Oxidant Status in Patients With Immune Thrombocytopenia (ITP) and the Role of an Adjuvant Antioxidant Therapy

Brief Summary: Oxidative stress occurs as a result of increased activity of free radical-producing enzymes, decreased activity of free radical-removing enzymes, and insufficient levels of antioxidants. The most sensitive molecules to oxidation are lipids. Loss of cell membrane elasticity, increased cell fragility, and a shortened cellular life span results from oxidation of cell membrane lipids.

Detailed Summary:

Free oxygen radicals may have an effect on the structural and functional damage of platelets and plays a role in pathogenesis of thrombocytopenia in both, acute and chronic ITP.

Selenium is an essential mineral found in small amounts in the body. It works as an antioxidant, especially when combined with other antioxidants as vitamin E , A and C. Antioxidants neutralize free radicals and may reduce or even help prevent some of the damage they cause.

aim of this study is to assess oxidant and antioxidant systems initially in patients with acute and chronic immune thrombocytopenia (ITP) and 6 months later.Another aim of the study is to evaluate effect of antioxidant therapy on bleeding score, platelet count and antioxidant status during 6 months follow-up.

Sponsor: Ain Shams University

Current Primary Outcome: oxidant status in ITP [ Time Frame: 6 month ]

Original Primary Outcome: Same as current

Current Secondary Outcome: antioxidant therapy [ Time Frame: 6 months ]

Original Secondary Outcome: Same as current

Information By: Ain Shams University

Dates:
Date Received: January 6, 2013
Date Started: March 2013
Date Completion: September 2013
Last Updated: January 8, 2013
Last Verified: January 2013