Clinical Trial: Psychopathology, Disordered Eating, and Impulsivity as Predictors of Outcomes of Bariatric Surgery

Study Status: Enrolling by invitation
Recruit Status: Enrolling by invitation
Study Type: Observational

Official Title: Psychopathology, Disordered Eating, and Impulsivity as Predictors of Outcomes of Bariatric Surgery

Brief Summary: This study will evaluate the relationship between psychopathology, disordered eating, and impulsivity (measured by clinical interview, self-report measures, and objective testing) on changes in weight and psychosocial status in the first two years after bariatric surgery. Participants will be 300 adults who plan to undergo bariatric surgery. Participants will complete four assessments over a two-year period, one at baseline (before surgery) and 6, 12, and 24 months after surgery. Each assessment will include computer tasks, surveys, clinical interview, urine test, waist circumference and height/weight measurement. The investigators will track how psychopathology, disordered eating, and impulsivity are related to changes in weight and psychosocial status following bariatric surgery.

Detailed Summary:

Psychosocial Status and Psychopathology in Candidates for Bariatric Surgery:

Extreme obesity is associated with a significant psychosocial burden, including impairments in quality of life, body image, sexual behavior and other areas of psychosocial functioning. While this distress is believed to contribute to the decision to have bariatric surgery, its impact on postoperative outcomes is less clear. At present, little is known about the physiological and behavioral contributions to success or failure of bariatric surgery. Regardless, weight regain after bariatric surgery is frequently attributed to preoperative psychosocial and behavioral factors. More specifically, there has been a great deal of interest in the presence of formal psychopathology in bariatric surgery patients and its potential contribution to postoperative outcomes. At least six studies have described rates of psychopathology in candidates for bariatric surgery using structured diagnostic instruments. Lifetime rates of any psychiatric diagnoses ranged from 36.8%-72.6%, higher than those reported in most studies of the general population. Mood disorders were the most frequent diagnoses, seen in 22.0%-54.8% of patients. Substance use disorders (SUDs) were found in up to 35.7% of patients and alcohol abuse or dependence in up to 33.2%. Binge eating disorder (BED), defined as eating an unusually large amount of food within a short period of time coupled with a loss of control over eating, has been diagnosed in 4.6% to 27.1% of patients. Current diagnoses (as compared with lifetime) were less common, reported in 20.9%-55.5% of candidates for surgery. Mood disorders were diagnosed in up to 31.5%. BED ranged from 3.4%-41.9%. Current substance use was seen in less than 2% of patients. (Note. The lower percentages of those with current psychopathology, as opposed to lifetime psychopathology, are
Sponsor: University of Pennsylvania

Current Primary Outcome: Change from baseline weight (kg) [ Time Frame: 6 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of Pennsylvania

Dates:
Date Received: May 10, 2016
Date Started: December 2015
Date Completion: November 2020
Last Updated: May 13, 2016
Last Verified: May 2016